Daniel Arzani and Eboue Kouassi have both likely been ruled out for the season with cruciate injuries.
Celtic boss Brendan Rodgers confirmed both players’ seasons appear to be over at a press conference.
Kouassi played on for more than 10 minutes on Sunday after treatment without realising the severity of his injury.
Arzani was stretchered off after only 18 minutes of his Celtic debut against Dundee on Wednesday.
The Hoops manager told the press that both players are likely to miss the rest of the season with the same injury.
Rodgers said: “We’re waiting on the scans, but it looks unfortunate. It looks like we’ll have two cruciate injuries in a week.”
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This double setback is the latest in a long list of recent injuries for Celtic to deal with.
A cruel blow
The news that two of Celtic’s fringe players are out indefinitely comes as a cruel blow to both.
Celtic fans are united in their sorrow for both players.
Tomorrow Celtic welcome Hearts to Parkhead in a crucial Scottish Premiership encounter.
Celtic can close the gap on Hearts to two points, having played a game less than the Jambos.
Hearts have their own injury crisis at the moment, but will be hoping to continue their fine start to the season.
With both squads appearing threadbare, tomorrow may just turn out to be the survival of the fittest.